García-Marín et al. analyzed 133 sinonasal ITAC for the presence of CD8+ TIL and PD-L1 expression, and showed that: (1) there is a significant association between density in CD8+ TIL and expression of PD-L1, with several ITAC characterized by high intratumoral CD8+ TIL density displaying also PD-L1 positivity in cancer cells and stromal macrophages; (2) CD8+ TIL density was associated with OS irrespective of stage and tumor subtype, with ITAC with high CD8+ TIL density being associated with remarkably better prognosis when compared to those with null-to-low CD8+ cell infiltrate. This evidence concerns the gene CD274 and cancer.