PTHLH and brain ischemia: More solid data have been published regarding the role of PTHrP as a modulator of cerebral vasculature, which can be summarized as follows: PTHrP is secreted in the endothelium of the cerebral microvasculature after brain ischemia; the administration of exogenous PTHrP enhances vasodilation in an in vitro model of cerebral vasculature; and the administration of PTHrP reduced the size of a brain infraction in an in vivo model of rats [30,31].