More recently, the clinical evidence of neuropsychological symptoms in patients affected by idiopathic and post-surgical hypoparathyroidism [9,10], lacking systemic PTH effects and the recently available human-recombinant PTH-substitutive therapy, has rekindled the interest in the possible effects of PTH and/or its related peptides on the CNS. This evidence concerns the gene PTH and hypoparathyroidism.