IGHE and Increased total eosinophil count: Immuno-profiling showed an endotype 2 inflammation in seven patients (25%), with 4/7 ascribed to tissual eosinophilia (tissue eos ≥ 10/hpf), 1/7 presented total IgE > 100 and 2/7 presented tissual eosinophilia and total IgE > 100 and 1/7 (mean total IgE 227.66 ± 32.78, median total IgE = 236, range 184–263).