In the dominant inheritance model, there was reported to be a significant connection between the VWF-TT vs. (TC + CC) genotypes and the risk of stroke, with an OR = 9.3, (95%) CI (4.8704 to 17.8857), RR = 2.85 (2.0615 to 3.945) and p < 0.0001. The gene discussed is VWF; the disease is stroke disorder.