CD4 and nonpapillary renal cell carcinoma: Opioid-exposed tumors presented a trend towards a more immunosuppressive immune infiltrate phenotype, with M1 macrophages and T cells CD4 memory resting presenting a statistically significant decreased expression (defined as p < 0.05) in opioid-exposed ccRCC specimens compared with non-exposed ccRCC specimens, as shown in Figure 7A,B.