As a consequence, Dravet patients fail to produce a sufficient level of functional channel and undergo a number of impairments actually correlated with a Nav1.1 LoF effect; but how is this decrease of Nav1.1 activity, which would predict reduced excitability in the brain, correlated with the occurrence of epileptic seizures, thus with an increase in excitability? The gene discussed is SCN1A; the disease is Seizure.