Importantly, it has to be considered that, because of the prevalence of Nav1.1 in regulating the excitability of GABAergic interneurons, prescription of antiepileptic drugs which non-selectively block Na channels is not recommended in Nav1.1-related epilepsies because this could worsen the crisis provoked by the decrease of inhibitory activity; conversely the best approach to design a drug based therapy could imply an enhancement GABA production or stability. Here, SCN1A is linked to epilepsy.