PI3K/Akt/mTOR signals, promoted by point mutations of PI3K and Akt and by inactivity of the phosphatase and tensin homolog (PTEN), play an important role in the regulation of the proliferation and apoptosis of cancer cells, especially from ovarian, gastric and breast neoplasms [44,45,46]. Here, AKT1 is linked to breast neoplasm.