PIM1 and acute erythroid leukemia: Researchers found that aqueous cinnamon extract is capable of inhibiting Pim-1 thanks to the bond of its ingredients to the structure of this kinase; in fact, Pim-1 has a novel hinge region and a unique hinge region, a sequence which links the fragment antigen binding region to the fragment crystallizable region of the protein [43] and to which natural compounds of cinnamon tie, determining apoptosis of cells of erythroblastic leukemia.