PIM1 and acute erythroid leukemia: Kim and his group [43] studied proviral insertion in murine lymphomas-1 (Pim-1), a proto-oncogene with important roles in the proliferation and differentiation of cells, which is overexpressed in erythroblastic leukemia, gastric carcinoma, prostate cancer, bladder cancer and is related to a poor prognosis; it acts via phosphorylating the anti-apoptotic molecules of Bad and preventing apoptosis.