CD8A and cancer: It has been also demonstrated that there are differences between oral and subcutaneous administration of aqueous cinnamon extract; in fact, an oral treatment of more of 48 h inhibits the growth of tumor cells via apoptosis more strongly than that of a subcutaneous one through an important reduction in pro-angiogenic molecules and pro-inflammatory cytokines, while a subcutaneous administration determines a major activation of cytotoxic CD8+ T cells with an anti-cancer effect.