GCKR and metabolic dysfunction-associated steatotic liver disease: Genetic factors, such as mutations in genes encoding patatin-like phospholipase domain–containing protein 3 (PNPLA3, I148M, rs738409), glucokinase regulatory protein (GCKR, rs780094) and squalene-synthase (FDFT1, rs2645424), also increase the risk of NAFLD [45].