According to the calculated ROC optimal cut-off point values, pre-treatment TF activity > 13.32 U/mL and pre-treatment PAI-1 concentration > 36.46 ng/mL are positively correlated with breast cancer recurrence (HR = 14.33, 95% CI = 1.81–113.28, p = 0.0116; HR = 8.39, 95% Cl = 1.07–65.58, p = 0.0427, respectively). The gene discussed is SERPINE1; the disease is breast cancer.