Aco2 activity was significantly lower in the 26 ALS patients than in the 22 healthy controls: the value range was 146.55 to 368.75 mU/mg in ALS patients versus 209.41 to 541.41 mU/mg in controls (Student’s t = −2.9; p < 0.05) (Figure 1). Here, ACO2 is linked to amyotrophic lateral sclerosis.