Exclusion criteria applied to (1) 125 (12.2%) with missing C-reactive protein (CRP) measurement at the time of PE diagnosis, (2) 43 (4.2%) patients with cardiac arrest as the presenting symptom, (3) 96 (9.3%) with other acute severe cardiopulmonary or infectious disease and (4) 14 (1.4%) patients with PE recurrence, who were already enrolled in PERGO. This evidence concerns the gene CRP and infectious disease.