TNF and obesity due to melanocortin 4 receptor deficiency: Akram’s study concluded that periodontal inflammation has a greater impact on the levels of biomarkers in GCF than obesity does, while whether patients having chronic periodontitis andobesity have elevated resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β GCF levels compared to nonobese individuals remains debatable [24].