In addition, Tahir et al. [52] used the serological analysis of a recombinantly expressed cDNA clone (SEREX) to screen for autoantibodies in serum samples from patients with IH induced by the CTLA-4 inhibitor ipilimumab, the PD-1 inhibitor nivolumab, or a combination of two ICIs, which revealed that antiguanine nucleotide-binding protein G subunit alpha (GNAL) and anti-integral membrane protein 2B (ITM2B) autoantibodies were significantly increased. Here, ITM2B is linked to isolated hemihyperplasia.