PD-1/PD-L1 inhibitor-related IH has ACTH deficiency in nearly 100% of cases [37], while TSH, GH and FSH/LH deficiency are less common, and its incidences were 11.8%, 13.3% and 18.8% of the treated population, respectively [37]. This evidence concerns the gene CD274 and isolated hemihyperplasia.