Previous data suggest that the presence of homozygous ancestral-natural-type AA alleles of SNP OPRM1 (A118G/dbSNP rs1799971-G) protects against pain perception and reduces problems that derive from pain perception, which preserves mobility, improves self-care, reduces anxiety-related problems in patients, and diminishes activities of daily living-related problems. Here, OPRM1 is linked to Anxiety.