A meta-analysis of cohort studies showed that microalbuminuria (urinary albumin 30–300 mg/d) and macroalbuminuria (urinary albumin > 300 mg/d) increased the risk of developing coronary heart disease by 50% and 200%, respectively, compared with normoalbuminuria, irrespective of other risk factors including T2DM [59]. This evidence concerns the gene ALB and coronary artery disorder.