CGA and posterior cortical atrophy: Although some investigators did not observe a significant association of CgA expression with OS or disease progression in surgically treated patients with clinically localized PCa [19], other studies showed that the percentage of CgA-positive cells exceeding 1%, 5% or 10% in biopsy specimens of locally advanced PCa was a risk factor for distant metastases, PSA progression-free survival and recurrence [15,20,21].