GBA1 and Gaucher disease: Gaucher disease (GD) is the most common of the lipid storage disorder, caused by GBA1 mutations, resulting in the deficiency of the lysosomal enzyme glucocerebrosidase (GCase) activity and the accumulation of the lipid substrates glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph) within the lysosomes of macrophages [1,2].