Concordantly, miR-16-5p is reported to have functions on resisting proliferative signaling and subduing angiogenesis, as its downregulation seems to activate the PI3K/AKT/mTOR, ANXA11/AKT and VEGFA/VEGFR1/AKT pathways to promote PCa cell proliferation [33]. Here, AKT1 is linked to posterior cortical atrophy.