On the other hand, MAT2A was found to be downregulated in different tumor types, including bladder urothelial carcinoma (BLCA), kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), and thyroid carcinoma (THCA), which were marked in blue (Figure 3). The gene discussed is MAT2A; the disease is chromophobe renal cell carcinoma.