MAT2A was upregulated in cholangiocarcinoma (CHOL), colon adenocarcinomas (COAD), glioblastoma (GBM), head and neck squamous cell carcinoma (HNSC) with human papillomavirus (HPV) infection, LIHC, pheochromocytoma and paraganglioma (PCPG), and stomach adenocarcinoma (STAD), which were marked in red (Figure 3). This evidence concerns the gene MAT2A and hereditary pheochromocytoma-paraganglioma.