MTOR and glioblastoma: For example, the inhibition of HIF1α (hypoxia-inducible transcription factor 1α) and mTOR signaling pathways mediated by rapamycin or mTOR silencing has been shown to reduce the ability of GBM cells to acquire genetic and/or phenotypic characteristics of endothelial cells, termed vasculogenic mimicry or transdifferentiation [27,51].