Furthermore, in this study, we were able to show that β-catenin was found at high levels in the filtrated CD63+ fraction, with mono-cultured GBM cells with/without therapy showing the same amount of β-catenin in the EVs, whereas a higher amount of β-catenin was detectable in the EVs of co-cultured GBM cells upon therapy compared to the unstimulated controls. This evidence concerns the gene CD63 and glioblastoma.