When analyzing the expression of the EMT markers β-catenin, L1 cell adhesion molecule (L1CAM), and snail family transcriptional repressor 2 (SNAIL2), the surviving PCa showed significant induction of all three markers upon stimulation with TMZ+AT101/AT101 after 3 or 6 days of treatment, respectively (Figure 3A). Here, L1CAM is linked to posterior cortical atrophy.