Hyperforin, a TRPC6 agonist obtained from the Hypericum perforatum plant, was shown to reduce Aβ levels and improve behavioral performance in AD animal models [106].In addition, hyperforin elevates intracellular calcium concentrations by activating TRPC6 without activating other isoforms, such as TRPC1, TRPC3, and TRPC4 [212]. This evidence concerns the gene TRPC6 and Alzheimer disease.