ADAM17 and Sjogren syndrome: In addition, the overexpression of ADAM-17 was detected in Sjӧgren’s syndrome in which pathological neovascularization was regulated by VEGF-A-stimulated ADAM17-dependent crosstalk between VEGFR2 and NF-κB [105] and ADAM17 may be involved in a cascade regulating the salivary gland fibrosis observed in Sjögren’s syndrome.