PPARG and systemic sclerosis: Several years ago, researchers demonstrated the expression of PPARγ in normal dermal fibroblasts and found that PPARγ inhibition could abrogate the TGFβ-induced collagen gene expression, inhibit myofibroblast differentiation, and repress Smad-dependent gene transcription; in addition, a reduction in PPAR-γ expression was observed in systemic sclerosis [143].