In RA, TGF-β1 acts both as a pro-angiogenic molecule, predominantly in the synovial membrane [32], and as an activator of the synthesis of pro-inflammatory cytokines [32], metalloproteinases [33], and various fibrinolytic factors responsible for tissue remodelling, such as aggrecanase [34] and urokinase-type plasminogen activator [35]. Here, TGFB1 is linked to rheumatoid arthritis.