While DC-SIGN was reported to enhance trans-infection of CD4+ lymphocytes [7,8,12], this CLR was also reported to be essential for the regulation of MHC-I- and MHC-II-mediated antigen presentation upon HIV-1 internalization [13,14,15,16] and for modulating TLR-driven innate immune responses [17,18]. This evidence concerns the gene CD209 and infection.