In diabetes, hyperglycemia-induced oxidative stress due to myocardial mitochondrial perturbations triggers inflammatory signaling factors, such as nuclear factor-κB (NF-κB) and NLRP3 inflammasome, which contribute to the severity of MI-related injury, adverse cardiac remodeling, and heart failure [66,67]. The gene discussed is NLRP3; the disease is myocardial infarction.