Catechin shows effectiveness as anti-inflammatory, increasing memory, antidiabetic, anticancer, bactericidal, anti-arthritis, hepatoprotection and neuroprotection, through activation of NF-κB, TLR4/NF-κB, Nrf-2, COMT and MAPKs pathways [31,32]. This evidence concerns the gene NFKB1 and arthritic joint disease.