It is well-known that centrally applied Ucn2 elicits anorexia and hyperthermia [20,24,25,26] via activation of the central CRH type 2 receptors [21] We hypothesized that the responsiveness to Ucn2 changes during the course of aging, similarly to other catabolic mediators, such as leptin or alpha-MSH [6,7,27,28]. Here, POMC is linked to Anorexia.