Similarly, in this condition, other AMD reminiscent abnormalities, such as basal laminar deposits, thickening of BM with drusen-containing deposits, RPE and photoreceptor degeneration, are described following a high fat diet in a mouse model heterozygous for the Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha (Pgc-1α). The gene discussed is PPARGC1A; the disease is age-related macular degeneration.