However, the metabolites excessive in SIRT2 KO mice (p-anisic acid, 3-ureidopropionic acid, dihydrouracil, p-cresol sulfate, alanylglycine, daidzein, dihydrothymine, 5-methoxyindoleacetate, and vinylacetylglycine) were positively correlated with NAFLD phenotypes (Figure 9B). This evidence concerns the gene SIRT2 and metabolic dysfunction-associated steatotic liver disease.