Combined with the results that serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were significantly elevated in SIRT2 KO mice fed with HFCS compared to those of WT mice (Figure 3C), these data collectively indicate an aggravated severity of liver dysfunction in SIRT2 KO mice. The gene discussed is GPT; the disease is Decreased liver function.