Similarly, β-caryophyllene and α-humulene have been shown to possess anti-inflammatory properties [60], whereas β-caryophyllene also exhibits anxiolytic and anti-depressant activities thanks to its ability to bind to the cannabinoid receptor subtype 2 (CB2) [61], thus suggesting an additive or synergistic effect with CBD in alleviating anxiety and depressive disorders. This evidence concerns the gene CNR2 and depressive disorder.