The top 20 genes highly expressed in the tumor microenvironment region of ARPC (TME-ARPC) and de novo NEPC (TME-de novo NEPC) are shown in Figure 4A. The expression of RBFOX3, PAGE4, and SERTM2 were higher in the TME-ARPC region than in the TME-de novo NEPC region. Here, RBFOX3 is linked to neoplasm.