The authors showed that in bladder cancer there was a positive correlation between HIF1A expression and both immune suppressive (PD-L1, Tregs, MDSCs, and M2 macrophages) and anti-tumour immune (CD8+ T cells, NK cells, M1 macrophages, and IFN response) gene signatures [24]. The gene discussed is CD274; the disease is urinary bladder carcinoma.