When comparing down-regulated genes in AML-MSCs versus D-MSCs—AML-MSCs secreted 343 identified proteins significantly lower than D-MSCs—COL6A1, TGFB, GAS6, PDGFA, PDGFRB, SERPINA3, SERPINA7, SERPINE2, VCAM1, CFH, C3, and others (Tables S2 and S3, Supplementary Materials). This evidence concerns the gene SERPINE2 and acute myeloid leukemia.