Among 86 proteins higher expressed in AML-MSCs and R-MSCs than in D-MSCs, the expression of 40 proteins decreased in remission: FTO, CAVIN3, CTSV, LMAN1L, CLTB, GAPD, HNRNPA3, IGFBP5, GSN, PPIA, COL18A1, PODN, CXCL12, LSM1, HLA-DRB1, HMGN1, NME1, PSMA1, PSMB5, PDIA3, PCLO, SEC23, PRSS3, GDI1, RTN4, SSBP1, SLC30A9, TSSK4, TPM2, LSM3, UBE2V1, ISG15, and others. Here, ISG15 is linked to acute myeloid leukemia.