In contrast to KCs, the Clec4f-Cre mediated excision of Hfe did not occur in splenic macrophages (sMF) nor in bone-marrow-derived macrophages (BMDMs) (Figure 1D), reinforcing the finding that HfeClec4fCre mice carry a selective Hfe-deficiency in KCs. The gene discussed is HFE; the disease is dry eye syndrome.