MiRNAs may regulate G1/S transitions by targeting important cell cycle regulators such as CDK1, CDK2, CDK4, and CDK6, as well as cyclin D1, D2, and E. MiR-195 binds to the 3′-UTR of CDK6 mRNA to negatively regulate CDK6 expression in gastric cancer. The gene discussed is CDK6; the disease is gastric cancer.