Muhammad et al. observed that bitter gourd extract application to breast cancer cells led to the induction of autophagosome-bound Long Chain 3 (LC3)-B, the accumulation of p62/SQSTM1 (p62) protein, an enhanced phospho-AMPK expression, as well as the downregulation of the mTOR/Akt signaling pathway. Here, SQSTM1 is linked to breast cancer.