The main transduction pathways activated by adiponectin/AdipoRs/APPL1 axis include JAK/STAT, LKB1/AMPK/mTOR, AMPK/Sirt1/PGC1α, NF-kB, JNK and MAPK, sustaining breast tumor development and progression through the induction of cell proliferation and survival, cell cycle progression and anti-apoptotic response [18,59] (Figure 2B). This evidence concerns the gene ADIPOQ and breast neoplasm.