On the other hand, we examined the cytokine and chemokine expression of the hepatic endothelial cells and found 14 cytokines (CD105, CD147, CXCL8, EGF, CXCL16, Midkine, CD26, CXCL1, CD31, VEGF, CCL20, ANGPT2, VCAM-1, and TSP-1) that showed at least a 10% difference after the co-culture with melanoma cells compared to the original protein profile of the hepatic endothelial cells. This evidence concerns the gene ANGPT2 and melanoma.