According to our results, we assume that our results indicate that the upregulation of the IL11RA gene in the invasive melanoma cells is triggered by HHSECs as well as in primary melanoma samples with liver metastasis, suggesting that IL11RA may play a possible role in the liver metastasis of primary melanoma cells; however, further investigations are necessary to test this hypothesis. This evidence concerns the gene IL11RA and melanoma.