Figure 7A–D illustrates that endothelin, P-selectin, VCAM-1, and ICAM-1 concentrations in heart homogenates of HT mice treated with PEG–AgNPs were significantly higher when compared with saline-treated HT group (p < 0.05) or PEG–AgNPs-treated normotensive group (p < 0.01–p < 0.05). This evidence concerns the gene ICAM1 and hematocrit.