STAT3 and hepatocellular carcinoma: One example of this, found in HCC, is represented by the tumor suppressor WT1-AS, which has a binding site in the promoter region of WT1; this binding, demonstrated by reporter constructs and WT1-AS overexpression, downregulated the expression of WT1, thus promoting cell apoptosis by suppressing the JAK/STAT3 signaling pathway [147].