ALKBH3 and hepatocellular carcinoma: Furthermore, in the hypoxic microenvironment, HIF-1α, a master regulator of hypoxia, can induce the expression of ALKBH3-AS1; Lu and colleagues demonstrated that the half-life of ALKBH3 mRNA was reduced after silencing ALKBH3-AS1, suggesting that the antisense lncRNA can exert an oncogenic role by enhancing ALKBH3 mRNA stability in HCC cells [48].