Interestingly, authors identified unexpected TP53 and/or RB1 negative SCLCs and peculiar STK11 mutations, suggesting a new classification of SCLC including three different molecular subgroups: RB1 and/or TP53 wild-type SCLCs, STK11 mutated SCLCs, and finally, those SCLCs derived from NSCLC and characterized by peculiar driven mutations such as EGFR [19]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.