An 82-year-old patient underwent staging surgery on 26 September 2016 with a total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, pelvic and periaortic lymph node biopsies, and omentectomy for a stage IVB uterine serous carcinoma, with HER2 overexpression. The gene discussed is ERBB2; the disease is endometrial serous adenocarcinoma.