To determine whether soft tissue melanoma expresses SHH and its signals Gli1 and Gli2, we performed an immunohistochemical analysis of excised human melanoma specimens and normal skin tissues, and we observed the expressions of SHH, Gli1 and Gli2 not only in melanoma cells but also in tumor vascular endothelial cells in the stroma (Figure 1A). Here, SHH is linked to neoplasm.