Moreover, our data on MITF expression based on chromosome 3 status and pigmentation show that a negative correlation between MITF expression and pigmentation was also present within a set of disomy 3 tumours while chromosome 3 status was more strongly related to MITF expression: disomy 3 tumours with low pigmentations had higher MITF levels than disomy 3 tumours with high pigmentations, even though we only had five disomy 3 Ums with high pigmentations (Figure 1b). This evidence concerns the gene MITF and neoplasm.