In cutaneous melanoma, loss of MITF is related to a switch in EMT profile, from a benign and proliferative ZEB2 (zinc finger E-box binding homeobox 2)/SNAI2 (snail family transcriptional repressor 2) positive state to an invasive ZEB1 (zinc finger E-box binding homeobox 1)/TWIST1 (twist family bHLH transcription factor 1) positive state [43,44,45]. The gene discussed is ZEB2; the disease is cutaneous melanoma.