MITF and neoplasm: As a mutation in the MITF gene is associated with Waardenburg syndrome (which is characterized by a white forelock) [52], and the absence of the mouse homologue mi leads to severe pigmentation defects [19], one would expect non-pigmented tumours to have a low MITF, but Mouriaux [26] previously described a surprising inverse correlation between MITF IHC staining and UM pigmentation.