The gene set enrichment analysis on Cluster (C) 3, 4 and 5 showed a significant enrichment score for the ferritin related gene set (padj = 0.002, ES = 0.8) (Figure 3B) with a significant enrichment of FTL and FTH1 (adjp < 0.001): accordingly, patients belonging to these clusters were identified as the high ferritin group (HF). The gene discussed is FTH1; the disease is hydrops fetalis.