Although MMP8 and MMP3 and IL-1β are important inducers of inflammation in our hyperglycemic coculture model, the multi-omics data integration model showed that FGF2, GM-CFS and IL-10 are key pro-inflammatory cytokines that play a major role in periodontitis-induced inflammatory response in a hyperglycemic microenvironment. This evidence concerns the gene MMP3 and periodontitis.