KCNA1 and Sudden unexpected death in epilepsy: In summary, given that seizure-related respiratory failure is a suspected primary cause of SUDEP and that respiratory dysfunction is a shared feature of KCNA1 channelopathy in both patients and mouse models, we propose that individuals with epilepsy due to KCNA1 mutations should be assessed for respiratory performance to identify those at higher risk of SUDEP and to provide enhanced surveillance.