SCN8A and epilepsy: At least six genes have been identified that can modify epilepsy phenotypes in the Kcna1 global knockout (KO) mouse model including Cacna1a (a P/Q-type calcium channel α subunit gene) [94]; Mapt (a tau microtubule-binding protein gene) [95]; Bad (a BCL2-associated agonist of cell death gene) [96]; Scn2a (a Nav1.2 voltage-gated sodium channel gene) [97]; Scn8a (a Nav1.6 voltage-gated sodium channel gene) [98]; and Slc7a11 (a System x-c glutamate antiporter gene) [99] (Table 3).