Another study showed that administration of the flavone to human breast cancer cells (MCF-7) modulated the level of miR-21 and miR-16, reducing cell viability in a dose- and time-dependent manner, but also inducing apoptosis through the intrinsic and extrinsic pathways via upregulation of Bax/Bcl-2 expression [33]. The gene discussed is BCL2; the disease is breast carcinoma.