Since ANXA1 was recently found to be downregulated in multiple human cancers in vivo [42,43,44,45], the fact that the ANXA1 N-terminal associates with cancer biomarkers cytokeratins 8 and 18 [46] could provide some insights into tumor suppression by other annexins, including ANXA7. The gene discussed is ANXA1; the disease is neoplasm.