CTBP1 and lung carcinoma: Moreover, when CTBP1 was knocked out, its transcriptional suppression on JWA expression was completely removed; therefore, JAC4 was unable to exert subsequent inhibition of lung-cancer growth and metastasis via the CTBP1-JWA pathway in these CTBP1-deficient cells (Figure 8I–L and Figure S9E).