ARL6IP5 and lung cancer: To explore the underlying mechanisms of how JWA affects lung-cancer progression, Western blotting was performed, which showed that the molecular markers of EGFR, P-EGFR, P-AKT, and P-STAT3 (the downstream pathways of EGFR) were downregulated when the cells increased JWA expression; however, these markers were upregulated when JWA was knocked down (Figure 3A).