In addition, JAC4 phosphorylated and stabilized NEDD4L by JWA-triggered activation of the AMPK-signaling pathway; the phosphorylation of NEDD4L further accelerated the degradation of EGFR through enhanced ubiquitination at K716, therefore suppressing the progression of EGFR-driven lung cancer. The gene discussed is ARL6IP5; the disease is lung carcinoma.