DCHS2 and Schnyder corneal dystrophy: Three other variants in the DCHS2 gene were associated with typical clinical manifestations of SCD and hemolysis biomarkers, as variant rs17373874 (identified in 96 heterozygous and 52 homozygous children, p-value = 0.01, recessive model) is associated with pain crises, variant rs1352714 (identified in 85 heterozygous and 83 homozygous children, p-value = 0.005, dominant model) with lower LDH post-treatment and rs17031722 (identified in 12 heterozygous and 2 homozygous children, p-value = 0.017, dominant model) with higher LDH post-treatment (Figure 2b,c).